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KMID : 0368820050440010116
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Journal of the Korean Neuropsychiatr Association
2005 Volume.44 No. 1 p.116 ~ p.119
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Diabetic Ketoacidosis in a Schizophrenic Patient Treated with Olanzapine: A Case Report.
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Lee Jung-Sun
Kim Jin-Yong
Ahn Joon-Ho
Kim Chang-Yoon
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Abstract
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The use of olanzapine has been associated with clinically significant hyperglycemia (exacerbation of existing diabetes, newonset type 2 diabetes and diabetic ketoacidosis). We report a case of diabetic ketoacidosis (DKA) in 30-year-old male patient with schizophrenia who was on olanzapine. When he was admitted to the hospital because of DKA, he had been taking olanzapine for 43 months. 14 months before the admission, his fasting and 2 hour postprandial serum glucose levels were normal. He had no personal and family history of diabetes mellitus. He had no risk factor for diabetes mellitus except for obesity (body mass index:39.2 kg/m2). He also had no precipitating factors for DKA such as infection or myocardial infarction. Periodic monitoring for changes in serum glucose levels in patients taking olanzapine may be needed.
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KEYWORD
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Olanzapine Diabetic ketoacidosis, Side effects
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